Endocrine Abstracts

We undertook a retrospective audit of patients with primary hyperparathyroidism. Patients were identified from the Bradford Endocrine Database.About 101 patients were identified. 13 were incorrectly labelled and excluded. Case records of 88 patients; median age 64 (range 17–87) years, 69 F:19 M, were examined. At diagnosis median corrected calcium was 2.72 (range 2.45–3.69) mmol/l, median PTH 14 (range 3–182) pmol/l and mean 24 h urine cal...

Background: Acquired male secondary hypogonadism is a relatively common cause of referral to the endocrine clinic. However, the extent to which further investigation is required, and the indications for a trial of testosterone therapy, remain unclear. Aim To review the clinical/biochemical/radiological findings in men presenting with this condition.Methods: We performed a retrospective case analysis of 41 consecutive patients referred to our clinic over ...

A 34 year old male diagnosed with congenital adrenal hyperplasia (21 hydroxylase deficiency, salt wasting variety) shortly after birth. Initial presentation was poor feeding with hypoglycemia, pigmented scrotum with elevated 17-OH progesterone. He had a right orchidopexy at age 9 for undescended testis. He was admitted multiple times with adrenal crises during his childhood. He went through puberty and achieved height of 177 cm which is 75th centile. His sister also has CAH. H...

Background: There is evidence to suggest an association between hypothyroidism (overt and subclinical) and cardiovascular disease. It is unclear whether the set-point of the thyroid axis, within the normal range, may be related to vascular risk.Methods: We have reanalysed the data from the original Whickham study to assess BP in the entire cohort and its relationship to serum TSH within the reference range (0.3–6.0 mIU/L). Multivariate stepwise line...

The diet of patients exposed to stress had been shown to be low in fibre, low in fruit and vegetables, low in vitamins C and E, and beta-carotene, high in sugar, and high in saturated fat. The implications of these findings are two-fold: the diet associated with stress is similar to those in patients with features of the Metabolic syndrome (Met-S – visceral obesity, diabetes, hyperlipidemia, hypertension).Aim: The aim of the present study was to ass...

A 54 yr old man presented with a six-month history of palpitations, sweating and weight loss. He had a past history of hypertension, type II diabetes, asthma and was HIV-1 seropositive since 14 yrs and was taking potent anti-retroviral therapy: Nevirapine 200 mg bd; Kaletra 3 capsules bd; and didanosine ec 400 mg od.Investigations confirmed Graves thyrotoxicosis (fT4 72.1 pmol/l; TSH <0.01 mU/l; and TSH receptor antibody positive). He was initially t...

Introduction: The association between fatigue, functional status and subclinical hypothyroidism (SCH) remains unclear. The available data is not consistent, and this is likely to be due to selection bias in studies recruiting patients from clinic rather than unselected community populations. Only population surveys looking at prevalence of fatigue and functional status in SCH are likely to provide the answer.Objective and Methodology: We compared the pre...

Aim: There are few reports discussing incidence and characteristics of the whole group of Cushing’s syndrome patients in the literature. The aim was to establish the incidence of endogenous Cushing’s syndrome with in-depth analysis of their various subtypes in a well-defined population.Methods: Retrospective cross-sectional analysis of Cushing’s syndrome patients diagnosed between 2008 and 2017. A thorough search for patients was carrie...

Background: Male hypogonadotrophic hypogonadism is an increasingly common cause of referral to endocrine clinics. Subnormal testosterone levels are frequently observed in obesity, type 2 diabetes mellitus and in the elderly. Endocrine Society guidelines suggest stratification of investigations based on the degree of androgen deficiency, with full pituitary function testing and MRI recommended only in those with serum testosterone levels less than 5.2 nmol/L. However the eviden...

Aim: To assess the impact of acromegaly on quality of life (QoL) as evaluated by the acromegaly QoL (AcroQoL) questionnaire in Maltese patients with cured, controlled and uncontrolled acromegaly.Design: Cross-sectional survey study.Methods: The AcroQol questionnaire was completed by all patients during their routine outpatient visit. Clinical and hormonal data including GH and IGF1 levels were also taken at the time of survey.<...